1 Introduction

The following packages are maintained and supported under MetrumRG’s software development lifecycle (SDLC). For each MetrumRG package, we link its available user guide, website, vignettes, repository, and additional learning material if available. If the package is used extensively throughout the Expo, we also link to its introductory page.

All our tools are free and open-source. They are, however, built on and optimized for use on our Metworx platform.

2 MPN (MetrumRG Package Network) and pkgr

Create and manage curated, reproducible R package environments.

MPN is an open repository of ~1000 packages specific to PMX sourced from CRAN and Github that’s freely available and accessible to all. pkgr is a command line tool to help project collaborators quickly identify and install all the packages relevant to a given project.

3 bbr

Manage, track, and report modeling activities, through simple R objects, with a user-friendly interface between R and NONMEM®.

bbr is used to submit models, consume outputs and diagnostics, and iterate on models. It provides simple tagging and model inheritance trees to support the replication and external review of your work.

4 mrgsolve

Simulate from ODE-based population PK/PD and QSP models in R.

mrgsolve allows the modeler to create a model specification file consisting of R and C++ code that is parsed, compiled, and dynamically loaded into the R session. Input data are passed in and simulated data are returned as R objects, so disk access is never required during the simulation cycle after compiling. The resulting computational efficiency facilitates model exploration and application, during both model development and decision-making phases of a drug development program.